| Date | Location | Result | |
| Nov 13, 2021 | East Stroudsburg, PA | Gannon 13, East Stroudsburg 10 | Box score |
| Nov 06, 2021 | Shepherdstown, WV | Shepherd 55, East Stroudsburg 7 | Box score |
| Oct 30, 2021 | East Stroudsburg, PA | Shippensburg 24, East Stroudsburg 23 | Box score |
| Oct 23, 2021 | East Stroudsburg, PA | East Stroudsburg 35, Bloomsburg 14 | Box score |
| Oct 16, 2021 | West Chester, Pennsy | West Chester 42, East Stroudsburg 24 | Box score |
| Oct 09, 2021 | East Stroudsburg, PA | East Stroudsburg 27, Millersville 7 | Box score |
| Oct 02, 2021 | Kutztown, Pennsylvan | Kutztown 21, East Stroudsburg 14 | Box score |
| Sep 25, 2021 | Lock Haven, Pa. | East Stroudsburg 45, Lock Haven 21 | Box score |
| Sep 18, 2021 | East Stroudsburg, PA | East Stroudsburg 17, Mercyhurst 7 | Box score |
| Sep 11, 2021 | Slippery Rock, Pa. | Slippery Rock 22, East Stroudsburg 7 | Box score |
| Sep 02, 2021 | East Stroudsburg, PA | East Stroudsburg 35, Pace 14 | Box score |